Rich sits down with Caltech microbiome research scientist & microbiology professor Dr. Sarkis Mazmanian to talk about how gut microbes influence neurological health, behavior, and conditions like Parkinson’s, autism, and depression. To read more about Dr. Mazmanian and peruse the full show notes, go here👉🏾https://bit.ly/richroll831

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FILMED AND EDITED BY BLAKE CURTIS & DAN DRAKE
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TIMESTAMPS
00:00:00 Intro
00:01:29 Introduction To Microbiome Research
00:04:23 Defining The Microbiome
00:06:11 Acceptance Of The Microbiome
00:07:53 Caltech As A Research Environment
00:09:04 The Gut-Brain Axis
00:13:52 Co-Evolution Of Microbiota And Humans
00:18:25 The Hygiene Hypothesis
00:20:45 Factors Affecting Microbiome Health
00:21:35 Building The Microbiome
00:22:26 Prenatal And Early Life Microbiome
00:24:39 Flexibility Of Adult Microbiome
00:26:27 Microbiome And Potential For Disease Transmission
00:29:49 Sponsor Break
00:30:55 Genetics And Microbiome Interaction
00:32:42 Environmental Triggers And Microbiome
00:35:55 Parkinson's And Gut Microbiome
00:41:55 Autism And The Microbiome
00:45:42 The Gut-Brain Axis And 4EPS
00:47:58 Oligodendrocyte Biology And Myelination
00:49:42 Parkinson's And Alpha-Synuclein Aggregation
00:52:55 Inhibition Of Bacterial Protein As Therapy
00:54:09 The Vagus Nerve And Parkinson's
00:57:01 Challenges In Translating Findings From Rodents To Humans
01:01:31 Sponsor Break
01:02:37 FDA's Perspective On Microbiome-Based Therapeutics
01:05:14 Direct Testing In Humans
01:06:27 The Effect Size Of Drugs
01:07:35 Research Landscape Of Neurological Disorders
01:08:36 Microbiome And Depression
01:11:06 Bi-Directional Communication Between Gut And Brain
01:13:29 Future Interventions For Microbiome-Based Therapies
01:15:56 Challenges And Potential Of Fecal Transplants
01:19:05 Complexity Of Microbiome Data
01:21:35 Dream Experiment For Studying Microbiome Impact
01:26:29 Influence Of Gut Microbiome On Food Cravings
01:29:12 The Microbiome And Sugar Cravings
01:30:17 Microbiome's Potential Impact On Addiction
01:32:10 Impact Of Diet On Microbiome And Cravings
01:35:50 The Microbiome's Influence On Sentience
01:38:57 Lifestyle Factors And Microbiome Health
01:40:30 The Role Of Fiber And Plant-Based Diets
01:43:48 Challenges Of Microbiome Testing And Interpretation
01:46:27 Future Of Microbiome Research And Healthcare
01:48:16 Big Pharma's Stance On Microbiome Research
01:50:04 Big Pharma's Business Model
01:51:54 Intellectual Property And Genetic Modification
01:53:10 Challenges Of Genetically Modified Microbes
01:54:54 Axial's Clinical Approach
01:58:37 Parkinson's Intervention Development
02:01:34 Microbiology Renaissance
02:02:42 Educational Resources And Skepticism
02:04:12 Closing Remarks And Credits

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Hi I'm Rich Roll. I'm a vegan ultra-endurance athlete, author, podcaster, public speaker & wellness evangelist. But mainly I'm a dad of four. If you want to know more, visit my website or check out these two the NY Times articles:
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