"The Big Bang Theory" tackled some big issues. For this list, we’ll be looking at moments where this show put the laughs on pause and gave us all some real-life moments to consider. Our countdown includes difficult friends, career direction, women in science, and more! What’s YOUR favorite “The Big Bang Theory” episode? Let us know in the comments!

Watch more great "TBBT" videos here:
Top 10 Times The Big Bang Theory Got Serious -    • Top 10 Times The Big Bang Theory Got ...  
Top 10 Times Bernadette was a SAVAGE on The Big Bang Theory -    • Top 10 Times Bernadette was a SAVAGE ...  
Top 10 Most Unforgivable Big Bang Theory Moments -    • Top 10 Most Unforgivable Big Bang The...  

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