DESCRIPTION
K-1000 chewable tablet is a combination product containing Calcium, Vitamin D3
(Cholecalcif-
erol) and Vitamin K2
(menaquinone-7) that helps strengthen bones and aids in the treatment/pre-
vention of osteoporosis, osteomalacia, hypo-parathyroidism and other bone disorders or to
overcome deficiencies of calcium and Vitamin D3
in certain populations and disease states. It is
also used to improve and maintain bone mineral density (BMD), bone health and strength.
PHARMACOLOGICAL AND THERAPEUTIC PROPERTIES
Calcium:
Calcium is required for vascular contraction and vasodilation, muscle function, nerve transmis-
sion, intracellular signaling and hormonal secretion, though less than 1% of total body calcium
is needed to support these critical metabolic functions. Serum calcium is very tightly regulated
and does not fluctuate with changes in dietary intakes; the body uses bone tissue as a reservoir
for and source of calcium to maintain constant concentrations of calcium in blood, muscle, and
intercellular fluids.
The remaining 99% of the body’s calcium supply is stored in the bones and teeth where it
supports their structure and function. Bone itself undergoes continuous remodeling with constant
resorption and deposition of calcium into new bone. The balance between bone resorption and
deposition changes with age. Bone formation exceeds resorption in periods of growth in children
and adolescents, whereas in early and middle adulthood both processes are relatively equal. In
aging adults, particularly among postmenopausal women, bone breakdown exceeds formation,
resulting in bone loss that increases the risk of osteoporosis over time.
Vitamin D3
:
Vitamin D3
promotes calcium absorption in the gut and maintains adequate serum calcium and
phosphate concentrations to enable normal mineralization of bone and to prevent hypocalcemia
tetany. It is also needed for bone growth and bone remodeling by osteoblasts and osteoclasts.
Without sufficient Vitamin D3
, bones can become thin, brittle, or misshapen. Vitamin D3
sufficiency prevents rickets in children and osteomalacia in adults. Together with calcium,
Vitamin D3
also helps protect older adults from osteoporosis.
Vitamin D3
has other roles in the body, including modulation of cell growth, neuromuscular
immune function and reduction of inflammation. Many genes encoding proteins that regulate
cell proliferation, differentiation, and apoptosis are modulated in part by Vitamin D3
.
Vitamin K2
:
Vitamin K2
is believed to help by preventing calcium from being deposited in your arteries by
reducing arterial calcification. Vitamin K2
plays a central role in the metabolism of calcium, the
main mineral found in your bones and teeth. Vitamin K2
activates the calcium-binding actions of
two proteins, a matrix GLA protein and osteocalcin, which help to build and maintain bones.
SUPPLEMENT BENEFITS
K-1000 chewable tablets are used to prevent conditions related to calcium and Vitamin D3
deficiency such as:
a) Osteoporosis
b) Osteomalacia
c) Hypoparathyroidism
d) Musculoskeletal pain
K-1000 chewable tablets are also used to overcome calcium and Vitamin D3
deficiencies in
certain populations and disease states such as:
a) Postmenopausal women
b) Bone recovery after fractures
K-1000 chewable tablets may also be used to prevent or treat bone-related disorders such as
osteoporosis in people taking certain medication.
DOSAGE AND ADMINISTRATION
Take 1 tablet daily after meals or as directed by the physician.
* NIH (National Institute of Health)
Recommended Daily Allowances (RDAs) for Vitamin K2
*NIH (National institute of health)
CONTRAINDICATIONS
K-1000 must not be used in patients with:
Hypersensitivity to any of the active substances (Vitamin D3
or its analogues, calcium or Vitamin
K2
or its analogues).
Due to calcium / cholecalciferol components, K-1000 tablets must not be used in:
Hypercalcaemia and/or hypercalciuria
Nephrolithiasis (Renal calculi)
Hypervitaminosis D
Severe renal impairment
Metastatic calcification
WARNINGS AND PRECAUTIONS
This product should not be used in certain medical conditions, including:
High calcium/Vitamin D3
levels (hypercalcemia/hypervitaminosis D)
Fat mal-absorption syndromes as the absorption of Vitamin K2
is fat-dependent
Known allergy to calcium, Vitamin D3
or Vitamin K2
containing products
Cardiovascular disease (Heart/blood vessel disease). There is a risk of potential exacerbation of
cardiac disorders and arteriosclerosis related to persistent hypercalcemic effects during
therapeutic use of calcium/Vitamin D3
products.
Renal calculi (Kidney stones)
Renal diseases (Kidney disease). Cholecalciferol should be used with caution in patients with
impairment of renal function due to the potential exacerbation of hypercalcemic effects during
therapeutic use. #alnafaypharmacy