#biologyanimation #hollidaymodel #geneticrecombination #rethinkbiology
One of the first plausible models to account for the preceding observations was formulated by Robin Holliday. The key features of the Holliday model are the formation of heteroduplex DNA; the creation of a cross bridge; its migration along the two heteroduplex strands, termed branch migration; the occurrence of mismatch repair; and the subsequent resolution, or splicing, of the intermediate structure to yield different types of recombinant molecules.
Read more: https://www.ncbi.nlm.nih.gov/books/NB...