This video will help you understand the differences between the holiday blues and SAD, learn about the two types of SAD, and discover the possible causes and interventions for this seasonal mood disorder. Dr. Marks breaks down the science behind serotonin, sunlight, and melatonin, shedding light on how they relate to SAD. If you've ever wondered about the connection between mood and the changing seasons, this video offers valuable insights.

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References
Less SERT in spring and summer
Berger M, Gray JA, Roth BL. The expanded biology of serotonin. Annu Rev Med. 2009;60:355-66. doi: 10.1146/annurev.med.60.042307.110802. PMID: 19630576; PMCID: PMC5864293.

Light Therapy Inhibits SERT
Harrison SJ, Tyrer AE, Levitan RD, Xu X, Houle S, Wilson AA, Nobrega JN, Rusjan PM, Meyer JH. Light therapy and serotonin transporter binding in the anterior cingulate and prefrontal cortex. Acta Psychiatr Scand. 2015 Nov;132(5):379-88. doi: 10.1111/acps.12424. Epub 2015 Apr 17. PMID: 25891484; PMCID: PMC4942271.

Vitamin D3 vs D2
Radicioni, M., Caverzasio, C., Rovati, S. et al. Comparative Bioavailability Study of a New Vitamin D3 Orodispersible Film Versus a Marketed Oral Solution in Healthy Volunteers. Clin Drug Investig 42, 151–161 (2022). https://doi.org/10.1007/s40261-021-01...

Yang D, Gouaux E. Illumination of serotonin transporter mechanism and role of the allosteric site. Sci Adv. 2021 Dec 3;7(49):eabl3857. doi: 10.1126/sciadv.abl3857. Epub 2021 Dec 1. PMID: 34851672; PMCID: PMC8635421.

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