DNA recombination process- lecture explains about the DNA recombination holiday junction & process. http://shomusbiology.com/
Download the study materials here-
http://shomusbiology.weebly.com/bio-m...
Genetic recombination is the production of new combinations of alleles, encoding a novel set of genetic information, e.g., by the pairing of homologous chromosomes in meiosis, or by the breaking and rejoining of DNA strands, which forms new molecules of DNA. This last type of recombination can occur between similar molecules of DNA, as in the homologous recombination of chromosomal crossover, or dissimilar molecules, as in non-homologous end joining. V(D)J recombination in organisms with an adaptive immune system is a type of genetic recombination that helps immune cells rapidly diversify to recognize and adapt to new pathogens. Recombination is a common method of DNA repair in both bacteria and eukaryotes.
In eukaryotes, recombination also occurs in meiosis, where it facilitates chromosomal crossover. The crossover process leads to offspring's having different combinations of genes from those of their parents, and can occasionally produce new chimeric alleles. The shuffling of genes brought about by genetic recombination is thought to have many advantages, as it is a major engine of genetic variation and also allows sexually reproducing organisms to avoid Muller's ratchet, in which the genomes of an asexual population accumulate deleterious mutations in an irreversible manner.

Chromosomal crossover refers to recombination between the paired chromosomes inherited from each of one's parents, generally occurring during meiosis. During prophase I the four available chromatids are in tight formation with one another. While in this formation, homologous sites on two chromatids can mesh with one another, and may exchange genetic information.[1]

Because recombination can occur with small probability at any location along chromosome, the frequency of recombination between two locations depends on their distance. Therefore, for genes sufficiently distant on the same chromosome the amount of crossover is high enough to destroy the correlation between alleles.

Tracking the movement of genes during crossovers has proven quite useful to geneticists. Because two genes that are close together are less likely to become separated than genes that are farther apart, geneticists can deduce roughly how far apart two genes are on a chromosome if they know the frequency of the crossovers. Geneticists can also use this method to infer the presence of certain genes. Genes that typically stay together during recombination are said to be linked. One gene in a linked pair can sometimes be used as a marker to deduce the presence of another gene. This is typically used in order to detect the presence of a disease-causing gene.[2] Source of the article published in description is Wikipedia. I am sharing their material. © by original content developers of Wikipedia.
Link- http://en.wikipedia.org/wiki/Main_Page Material source: Molecular Biology of the Gene (4th Edition)
James D. Watson (Author), Alan M. Weiner (Author), Nancy H. Hopkins (Author)
Link: http://www.amazon.com/Molecular-Biolo...